VarExp: estimating variance explained by genome-wide GxE summary statistics
نویسندگان
چکیده
منابع مشابه
A Unified Framework for Variance Component Estimation with Summary Statistics in Genome-wide Association Studies.
Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, the standard method for estimating variance components in LMMs-the restricted maximum likelihood estimation method (REML)-suffers from several important drawbacks: REML requires individual-level genotypes and phenotypes from all samples in the study, is computationally slow, and produces ...
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1 Department of Psychiatry, Queen Mary Hospital, Hong Kong SAR, China; 2 Department of Psychiatry, Genome Research Centre and the State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong SAR, China. ABSTRACT Genome-wide association studies (GWAS) have become increasingly popular these days and one of the key questions is how much heritability could be explained b...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2018
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bty379